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"LOSE" and "LOOSE"
"Lose" means to fail to win or misplace. "Loose" means not tight or free. Ex.: I don't want to lose my keys. The button on my shirt is loose.
"THEN" and "THAN"
"Then" relates to time. "Than" is used for comparison. Ex.: First, we'll have lunch, and then we'll go for a walk. He is more experienced than I am.